CUMYL-4CN-BINACA (also known as CUMYL-CYBINACA or SGT-78) is an indazole-3-carboxamide based synthetic cannabinoid that has been sold online as a designer drug. It is a potent agonist for cannabinoid receptors CB1 and CB2, with in vitro EC50 values of 0.58 nM and 6.12 nM, respectively. In mice, CUMYL-4CN-BINACA produces hypothermic and pro-convulsant effects he CB1 receptor,[7] and anecdotal reports suggest it has an active dose of around 0.1 mg in humans.[8]
CUMYL-4CN-BINACA is metabolized to produce cyanide, raising concerns about liver toxicity.[6] There is one reported case of hyperthermia, rhabdomyolysis, and kidney failure associated with its use
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