Xylazine is a drug used for sedation, anesthesia, muscle relaxation, and analgesia in animals such as horses, cattle, and other non-human mammals.[1] It is an analog of clonidine and an agonist at the ฮฑ2 class of adrenergic receptor.[2]
In veterinary anesthesia, xylazine is often used in combination with ketamine. Veterinarians also use xylazine as an emetic, especially in cats.[3] It is sold under many brand names worldwide, most notably the Bayer brand name Rompun.[1] It is also marketed as Anased, Sedazine, and Chanazine.[4] The drug interactions vary with different animals.[5][6][7]
Xylazine has become a drug of abuse in the United States, where it is known by the street name “tranq”, particularly in Puerto Rico.[8] The drug is being diverted from stocks used by equine veterinarians and used as a cutting agent for heroin and fentanyl, causing skin sores and infections at injection sites, as well as other health issues.[9] Fentanyl mixed with xylazine is known by the street names “sleep-cut, zombie drug and tranq dope.”[10][11][12][13]
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